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Cefazolin
Patient
A priori
Bolus infusion
Continuous infusion
A posteriori
Bolus infusion
Continuous infusion
Advanced modelling
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Demographics
Patient ID (optional)
Sex
Female
Male
Weight (kg)
Age (years)
Creatinine
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Creatinine measurements
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Multiple
Serum creatinine value
mg/dL
µmol/L
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Albumin
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Albumin measurements
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Serum albumin value (g/L)
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A priori - bolus infusion
Limits
Target range (mg/L)
Level prediction for
unbound concentration
total concentration
Minimal Inhibitory Concentration
MIC (mg/L)
Time (x) up to which the area under the concentration-time curve (AUC₀–x) shall be calculated
AUC duration (h)
Dose recommendation parameters
Dose
500 mg
1000 mg
1500 mg
2000 mg
2500 mg
3000 mg
3500 mg
4000 mg
Dose interval
4 hours
6 hours
8 hours
10 hours
12 hours
Infusion duration (h)
Compare
Alternative regimen
Dose (mg)
Infusion duration (h)
Dose interval (h)
Calculate
Dose recommendation
Alternative regimen
A priori - continuous infusion
Limits
Target range (mg/L)
Level prediction for
unbound concentration
total concentration
Minimal Inhibitory Concentration
MIC (mg/L)
Time (x) up to which the area under the concentration-time curve (AUC₀–x) shall be calculated
AUC duration (h)
Dose recommendation parameters
Daily dose
1000 mg/24 h
2000 mg/24 h
3000 mg/24 h
4000 mg/24 h
5000 mg/24 h
6000 mg/24 h
7000 mg/24 h
8000 mg/24 h
9000 mg/24 h
10000 mg/24 h
11000 mg/24 h
12000 mg/24 h
Loading dose
no loading dose
500 mg
1000 mg
1500 mg
2000 mg
2500 mg
Duration of loading dose infusion
Infusion duration (h)
Compare
Alternative regimen
Daily dose (mg/24h)
Loading dose (mg)
Duration of loading dose infusion
Infusion duration (h)
Calculate
Dose recommendation
Alternative regimen
A posteriori - bolus infusion
PK parameters estimation
Exploration
Dosing information
Time of last dose
Dose (mg)
Dose interval (h)
Infusion duration (h)
Measurement
after 1 dose
after 2 doses
after 3 doses
after 4 doses
after 5 doses
in steady state
Level prediction for
unbound concentration
total concentration
First measurement
Time of blood sampling
Unbound concentration
Total concentration
Second measurement (optional)
Time of blood sampling
Unbound concentration
Total concentration
Estimate PK parameters
Limits
Target range (mg/L)
Level prediction for
unbound concentration
total concentration
Minimal Inhibitory Concentration
MIC (mg/L)
Time (x) up to which the area under the concentration-time curve (AUC₀–x) shall be calculated
AUC duration (h)
Dose recommendation parameters
Dose
500 mg
1000 mg
1500 mg
2000 mg
2500 mg
3000 mg
3500 mg
4000 mg
Dose interval
4 hours
6 hours
8 hours
10 hours
12 hours
Infusion duration (h)
Compare
Alternative regimen
Dose (mg)
Infusion duration (h)
Dose interval (h)
Calculate
Estimated PK parameters
Dose recommendation
Alternative regimen
A posteriori - continuous infusion
PK parameters estimation
Exploration
Dosing information
Date treatment initiation
Daily dose (mg/24h)
Loading dose
Duration of loading dose infusion
Infusion duration (h)
Level prediction for
unbound concentration
total concentration
First measurement
Time of blood sampling
Unbound concentration
Total concentration
Second measurement (optional)
Time of blood sampling
Unbound concentration
Total concentration
Estimate PK parameters
Limits
Target range (mg/L)
Level prediction for
unbound concentration
total concentration
Minimal Inhibitory Concentration
MIC (mg/L)
Time (x) up to which the area under the concentration-time curve (AUC₀–x) shall be calculated
AUC duration (h)
Dose recommendation parameters
Daily dose
1000 mg/24 h
2000 mg/24 h
3000 mg/24 h
4000 mg/24 h
5000 mg/24 h
6000 mg/24 h
7000 mg/24 h
8000 mg/24 h
9000 mg/24 h
10000 mg/24 h
11000 mg/24 h
12000 mg/24 h
Loading dose
no loading dose
500 mg
1000 mg
1500 mg
2000 mg
2500 mg
Duration of loading dose infusion
Infusion duration (h)
Compare
Alternative regimen
Daily dose (mg/24h)
Loading dose (mg)
Duration of loading dose infusion
Infusion duration (h)
Calculate
Estimated PK parameters
Dose recommendation
Alternative regimen
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Efficacy prediction at
Limits
Target range (mg/L)
Level prediction for
unbound concentration
total concentration
Minimal Inhibitory Concentration
MIC (mg/L)
Time (x) up to which the area under the concentration-time curve (AUC₀–x) shall be calculated
AUC duration (h)
Cefazolin administrations
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Cefazolin measurements
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Version 1.2 (04.07.2025)